The largest employers in the region by size of workforce are:

• University of Cincinnati 15,400 employees
• The Kroger Company 14,000
• Health Alliance of Greater Cincinnati 13,141
• The Procter & Gamble Company 12,000
• Fifth Third Bank 8,964
• Cincinnati Children's Hospital Medical Center 8,102
• TriHealth, Inc. 7,648
• Cincinnati Public Schools 7,589
• GE Transportation 6,800